Nanjing Liwei Chemical Co., Ltd

Knowledge

Tetrabutyltin: From Historical Context to Future Possibilities

Historical Development

The rise of organotin chemistry in the early twentieth century marked a step forward in both understanding and commercial chemistry. Chemists in Europe, eager for industrial alternatives, started tinkering with alkyl-tin compounds. Tetrabutyltin turned up as a product of ambition and tough market demands, shown in records from the 1930s, right around the time heavy industry leaned into synthetic organometallic compounds. In post-war years, this compound found early use in polymer stabilization and as a source for other organotin species. History repeats itself whenever innovation collides with necessity, and Tetrabutyltin gives an example of that loop.

Product Overview

Tetrabutyltin is an organotin compound with the formula Sn(C4H9)4. Its liquid nature and relatively high tin content make it a popular raw material for a range of industrial syntheses. In the world of specialty chemicals, it builds the backbone for manufacturing various mono-, di-, and tributyltin compounds, all vital for multiple applications in plastics, coatings, and agriculture. Occasionally overlooked, it quietly supports vast systems of modern industry.

Physical & Chemical Properties

The compound takes the shape of a clear to pale yellowish liquid, with a faint aroma that speaks to its organic roots. It weighs in at a molecular mass of about 405.1 g/mol, boiling at around 155°C under reduced pressure. Less dense than water at about 1.06 g/cm³, Tetrabutyltin floats, forming a separate layer if the two meet. Insoluble in water, it mixes well with most organic solvents. In terms of structure, four butyl groups latch tightly onto the tin atom, making the molecule both hydrophobic and capable of withstanding slow hydrolysis, though extended contact with strong acids or bases will break it down.

Technical Specifications & Labeling

Every container of Tetrabutyltin needs strict attention to purity, with most producers quoting a minimum purity of 97%. Reliable supply houses provide GC or NMR data to back their claims. Labels clearly note ‘Tetrabutyltin’, the CAS number 1461-25-2, batch number, hazard pictograms, as well as recommended storage conditions: tightly sealed, away from heat sources, and in well-ventilated spaces. Large drums need UN number 2786, and MSDS documentation follows each shipment to address health and environmental protocols.

Preparation Method

Most Tetrabutyltin comes from the direct alkylation of tin tetrachloride with butyl Grignard reagents or butyllithium. Factories use controlled environments because the reactants ignite easily and produce heat. The process runs in solvent like diethyl ether or THF, followed by fractional distillation under vacuum to collect pure Tetrabutyltin and separate out less pure fractions. The leftover by-products—magnesium salts or lithium chloride—need responsible handling and disposal.

Chemical Reactions & Modifications

Tetrabutyltin sees heavy use as a starting building block in organotin chemistry. It reacts with chlorine or hydrogen chloride to form tributyltin chloride or tributyltin hydride. Transalkylation reactions swap a butyl group for alternative alkyl chains, depending on target products. In strong acid, hydrolysis steps break butyl groups from the tin core, yielding a pathway to develop new catalysts or stabilizers. These reactions support everything from weather-resistant vinyl profiles to anticorrosive paints.

Synonyms & Product Names

Suppliers may call this chemical ‘TBT’, ‘Tetra-n-butylstannane’, or ‘Tetra-n-butyl tin’. Different catalogs might also reference names like ‘Tetrabutyltin(IV)’ or just ‘Tetrabutyl tin compound’. These labels reflect both traditional chemical nomenclature and branding for commercial markets. It all points back to the same four-armed organotin core.

Safety & Operational Standards

Direct exposure to Tetrabutyltin should remain minimal. Liquid splashes can irritate the skin, eyes, and respiratory system. Safety teams use gloves, goggles, lab coats, and chemical fume hoods. Ventilation systems inside manufacturing plants limit inhalation risk. Fire departments list this chemical as flammable and ask for foam or dry powder extinguishers nearby. Storage practices separate it from oxidizers and strong acids. Emergency responders expect clear signage and up-to-date material safety data sheets on site.

Application Area

Industry leans on Tetrabutyltin to synthesize tributyltin-based compounds for PVC stabilization, antimicrobial coatings for ships and underwater structures, and homogeneous catalysts for plastics or elastomers. Research groups see it as a precursor for cross-coupling reactions, making specialty compounds for drug discovery and electronics. The ability to break down into bioactive tin species means it also has some legacy use as a biocide. Tighter regulations have challenged older antifouling marine applications, but its role as a chemical intermediate survives ongoing scrutiny.

Research & Development

Research into alternatives for tributyltin-based additives remains an active field, as institutions across Europe and North America dedicate resources to lower-toxicity replacements. Universities publish work exploring the catalytic performance of tetrabutyltin-derived metal complexes, and test new routes to improved thermal stability in polymers. Academic labs often choose Tetrabutyltin for alloy precursor chemistry or for studying tin-organic frameworks in advanced batteries, bringing new momentum to old molecules.

Toxicity Research

The health and ecological impact of organotin compounds, especially tributyltin species derived from Tetrabutyltin, has prompted closer regulation and monitoring. In aquatic environments, tributyltin contamination has led to endocrine disruption in marine animals. Lab studies show Tetrabutyltin itself carries lower toxicity than its chlorinated offshoots, but still demands respect due to its lipophilic character—it can cross biological membranes and accumulate in fat-rich tissues. Ongoing toxicological studies use rodent models and in vitro assays to spell out thresholds for safe handling. Safety guidelines stand updated as researchers refine our understanding of both acute and chronic risks.

Future Prospects

Public health forces, regulatory agencies, and chemical manufacturers will keep shaping the future of Tetrabutyltin. Green chemistry movements push for benign solvents and non-toxic alternatives, driving investment into recycling and reuse strategies for tin-based waste. The compound’s proven track record in organometallic synthesis and catalysis still brings value, especially as researchers work towards more sustainable, controlled-release materials. Broader availability of high-purity Tetrabutyltin supports deeper research into energy storage, semiconductors, and advanced polymer technologies. Future discoveries will depend on smarter handling, honest talks about risk, and ongoing commitment to safety—in research, industry, and the community.



What is Tetrabutyltin used for?

The Backbone of Modern Chemistry

Tetrabutyltin isn’t a household name. Folks outside the chemical industry might never hear about it. Yet, so many things around us owe a bit of their existence to this clear, colorless liquid. Tetrabutyltin, part of the organotin compound family, shows up at an early stage of making things like plastics, pipes, wires, and even window coatings. It starts out as something simple—tin holding on to four butyl groups—then gets turned into substances that keep our world running.

Where It Pops Up in Daily Life

PVC, the tough plastic used in plumbing, window frames, and medical devices, often needs extra help to hold its shape and resist heat. Tetrabutyltin gets converted into other tin compounds called stabilizers, which protect PVC from breaking down under sunlight or during production. Every time someone turns on a shower using a PVC pipe, there’s a connection back to this compound.

Factories use tetrabutyltin as what chemists call a precursor. It acts like a parent chemical. Add in the right ingredients, heat, or catalysts, and suddenly you have dibutyltin or tributyltin compounds—each fine-tuned for specific roles in everything from making clear plastic sheeting to the coatings on solar panels. The path always starts with tetrabutyltin.

Safety and Environmental Impacts

Chemicals with the word “tin” often come with baggage. Tributyltin, especially, has harmed marine life and led to environmental restrictions. Tetrabutyltin itself isn’t the main culprit, but since it gets transformed into other forms, handling and disposal demand care. Workers in plants wear protective gear. Facilities build in steps to prevent leaks, and regulators watch over shipments.

The chemical industry learned the hard way about tin compounds leaching into rivers. Over time, stricter rules and better technology cut down on accidents. Anyone manufacturing or using tetrabutyltin has to stick to local and international guidelines. This commitment keeps harmful tin compounds out of fish, water, and eventually out of our food.

Why All This Matters

Most people never hold a bottle of tetrabutyltin, but the things made from it touch everyone’s life. As the world asks for safer, greener plastics and coatings, producers look for ways to make stabilizers from less toxic substances. Researchers keep searching for better options. Some companies already use “organic” stabilizers that leave tin out altogether. Results are mixed—performance or cost doesn’t always line up with society’s goals.

Replacing tetrabutyltin completely means solving both science and business puzzles. Until more sustainable methods win out, focusing on safe practices and strict oversight protects both people and the planet. Knowledge, vigilance, and a willingness to change when better answers appear—these keep industries moving toward a cleaner future. Trust builds when companies share information, follow safety standards, and invest in new solutions. The stuff inside a manufacturer’s tank rarely makes headlines. Still, pieces like tetrabutyltin show how small compounds shape bigger stories.

What is the chemical formula of Tetrabutyltin?

Understanding Tetrabutyltin’s Skeleton

Tetrabutyltin walks into the world of chemistry with a formula: C16H36Sn. It mixes four butyl groups—simple straight chains of carbon and hydrogen—with a single atom of tin as the backbone. The genius in this structure lies in its balance; organic and metallic, flammable yet slow to react under normal circumstances. People tend to gloss over what these formulas really mean. For me, staring at C16H36Sn brings back hours in the lab, cautiously handling tin compounds, knowing full well a spill meant not just a mess but potentially harsh consequences for health and environment.

Why Knowing the Formula Matters in the Real World

As soon as you see “tin,” alarms ring for anyone working around industrial chemicals. Tetrabutyltin plays a key role in the manufacture of other organotin compounds, and it finds its way into applications that stretch from stabilizers in plastics to potential intermediates in lab work. In places where quality control matters—factories, research, even waste disposal—getting the exact formula means getting safety right. It’s not about memorizing for a quiz; it’s about knowing what’s in the drum you’re handling.

Mistaking tetrabutyltin for a different organotin could lead to real trouble. Some tin compounds, especially those with more reactive partners, turn toxic or persist in the environment for years. This not only endangers those nearby but complicates cleanup efforts. C16H36Sn spells out what rescue teams, workers, or regulators deal with. No educated guess replaces precise data here.

Handling Hazards, Preventing Pitfalls

I remember a story from a chemical plant where a mislabeled drum led to a near-disaster. The label left off the exact formula, and workers took unnecessary risks thinking they had a less harmful cousin of tetrabutyltin in front of them. Safety protocols slipped. Exposure sent two folks home sick. Lessons like this shape how experts craft training and regulations. Clear chemical formulas, full names, emergency data ready to go—these become non-negotiable.

Even though C16H36Sn doesn’t strike fear at first glance, its persistence and potential for breaking down into more toxic relatives, such as tributyltin, add urgency. Tributyltin, for instance, stirred global concern as a major pollutant in marine paints. Small mistakes at the manufacturing level cascade into larger messes over time. There's no shortcut past the need for education—everyone handling or disposing of tetrabutyltin ought to respect more than just its formula.

Solutions for a Safer Future

Transparency forms the foundation. Every supplier must provide full safety data, right down to the molecular makeup. People in plants and labs need up-to-date training, and communities benefit when hazardous waste gets the treatment it requires according to best practices. Technology also lends a hand; modern tracking systems flag mismatches before small problems grow big. Regulators should lean on digital monitoring and stricter labeling, pushing companies to disclose everything—not just the name but what’s inside, starting with C16H36Sn.

Real stewardship doesn’t begin or end with formulas, but understanding tetrabutyltin’s—C16H36Sn—marks the start of responsible action, from personal decisions to industry-wide safeguards.

Is Tetrabutyltin hazardous to health or the environment?

Looking at Tetrabutyltin Beyond the Lab

I’ve spent plenty of years around industrial chemicals, and one thing that never changes: what looks stable in a controlled environment often creates real headaches once it escapes that world. Tetrabutyltin serves as a great example. The stuff often gets used in making other chemicals, including organotin compounds that show up in plastics, PVC, and even some pesticides. On paper, it’s not categorized as the scariest chemical out there. Yet, if you dig deeper, the risks gather quickly.

Health Impacts Can Sneak Up

Tetrabutyltin travels with a reputation for being less hazardous than its relatives, such as tributyltin, but that doesn’t make it safe. The fumes are flammable and can irritate the eyes and skin; even the vapor hangs in the air, affecting the respiratory system. Most people walking down the street don’t brush up against tetrabutyltin, but workers in chemical plants, refineries, and even people near facilities can end up exposed. If it seeps into water or food, it goes straight to the liver and kidneys, causing cell damage. OSHA and other regulators suggest tight exposure controls for good reason.

Environmental Damage Builds Quietly

Once chemicals like tetrabutyltin hit the environment, the chain reaction can last for years. Tetrabutyltin itself breaks down into more toxic compounds such as tributyltin. That’s where the environmental problems start to snowball. Tributyltin heads straight for aquatic life, harming everything from oysters to snails and fish. Even low concentrations disrupt hormone systems, causing reproductive issues and population declines. Contaminated sediment in rivers and harbors keeps leaking these toxins long after factories shut down. The loss of shellfish and fish stocks affects the economy and local diets. It’s not the kind of legacy communities sign up for.

Lessons from the Global Pushback

Watching European and Asian regulators clamp down on organotins taught me that money can’t come before public health. The International Maritime Organization banned tributyltin in ship paints because of its devastating effect on marine life. Companies learned to adapt, shifting to safer alternatives. That kind of pressure makes a difference, forcing innovation without emptying factories overnight. In places where laws lag behind, contamination levels stay higher, with communities seeing more cancers and developmental issues. It’s easy to see how a lack of vigilance quickly turns into a public health problem years down the line.

Cleaner Solutions in Reach

The chemical industry responds best to clear rules and good science. Mandating better protective gear for workers, stronger emission controls, and stricter discharge limits creates safer jobs and neighborhoods. New catalysts and additives often skip the use of organotins, and companies retool their lines faster than most people expect, especially when the law gives a clear deadline. Local monitoring makes it harder for illegal dumping to slip under the radar. Modern iot-enabled sensors now detect organotin traces in water instantly, letting regulators act before the problem balloons. These changes don’t just lower risk—they lay the groundwork for healthier communities and cleaner waterways. From where I stand, public engagement and tough standards get results, protecting people today and in the future.

How should Tetrabutyltin be stored and handled?

Walking into the World of Tetrabutyltin

Tetrabutyltin doesn’t pop up in dinner conversations, but you might find it in factories or labs working with chemical catalysts or specialty coatings. From personal experience in hazardous materials training, the difference between a controlled lab storage area and a messy backroom can mean the difference between routine work and a serious emergency. The risks with tetrabutyltin lie in its reactivity, toxicity, and the fumes it lets off if handled carelessly.

The Hazards Lurking in the Drum

Exposure to tetrabutyltin can irritate the skin, eyes, and lungs. It gives off vapors that build up in still air. Over time, breathing those vapors damages health, and skin contact brings rashes or worse. If a drum springs a leak near an open flame, the result might be toxic smoke or even fire. Working around dangerous chemicals means making safety a routine, not just a rule on paper.

Choosing the Right Spot

Pick a cool, dry room with steady airflow. Don’t stack it next to acids, oxidizers, or anything flammable. This chemical reacts strongly around certain materials and high temperatures. Never leave it in sunlight, not just because the label says so—heat speeds up decomposition, and fumes can build up. Place warning placards where people can see them. In my time working with chemical stocks, folks who cut corners with placement often paid the price later with corroded shelves or unexpected leaks.

Gearing Up for the Job

Gloves, eye protection, and a sturdy lab coat stay on whenever moving or handling tetrabutyltin. Keep chemical splash goggles and a face shield on hand if there’s a chance for a splash. In small workspaces, I never trusted my nose to warn me about fumes. Even in well-maintained labs, air monitoring makes a difference. Install a fume hood or use a locally exhausted bench. Respirators with organic vapor cartridges sit nearby in high-risk areas.

Keeping Everything Contained

Only store tetrabutyltin in tightly sealed, corrosion-resistant drums or glass bottles. Label everything clearly. Avoid transferring it between containers unless it’s absolutely necessary, and always use a closed system or a spill tray. More than once, I’ve seen a rushed transfer job lead to a puddle on the floor. Even small spills need prompt attention; soak up with inert adsorbent and ventilate the room fast. Never send used rags or contaminated garbage straight to the dumpster—waste must follow hazardous disposal regulations.

Training and Response Matter

Anyone working with this substance must know emergency drills by heart. Fire extinguishers, showers, and eye wash stations remain within arm’s reach. In the facilities where I trained, teams ran mock drills so every step felt like second nature. It’s not paranoia—it’s learning from past accidents and committing to never repeat them. Strong communication keeps newcomers and veterans on the same page, so no one’s caught off guard.

Solutions for the Road Ahead

Reducing risk takes a mix of sturdy policy and hands-on vigilance. Safer storage rooms or newer sensor technology improve odds, but people form the first and last line of defense. Updating safety data sheets and running regular checks stops bad habits from creeping in. By treating tetrabutyltin with the respect it demands, accidents won’t sneak up and ruin a day—or a career.

What are the safety precautions for working with Tetrabutyltin?

Spotting the Hazards

Tetrabutyltin pops up in many industrial settings, mostly as a stepping stone in making other chemicals. People who work with it get exposed to risks because it’s toxic, flammable, and doesn’t get along with acids or strong oxidizers. Breathing in its fumes or touching it directly can cause health problems, from irritated skin to serious organ damage. I remember a maintenance tech who joked about the odd smell, only to end up with a nasty rash and missed workdays. He didn’t think gloves were “worth the hassle.” It only takes a few bad experiences like that to realize what’s at stake.

Personal Protective Equipment

Working with tetrabutyltin calls for real gear, not just lab coats. Chemical-resistant gloves, splash goggles, and face shields come first. Standard latex gloves just don’t cut it here; I’ve seen nitrile or butyl types stand up much better after someone learned the hard way. A full-length apron and boots made from the right material give extra protection when moving containers. In spots where fumes might build up, respirators rated for organic vapors keep you out of the doctor’s office. Someone on my old crew used to say, “You feel silly now, but it’s better than looking silly in the ER.”

Getting the Workspace Right

Good ventilation stops fumes from settling in. I learned to spot the difference between spaces that circulate enough air and ones that trap vapors. Chemical fume hoods or local exhaust setups make life easier and safer. If indoor spaces don’t clear out the air quick enough, accidents add up faster than you’d expect. In one place I worked, a simple exhaust fan cut lingering smells and complaints by half.

While Handling and Storing Tetrabutyltin

Keeping tetrabutyltin sealed tight in metal or hard plastic containers blocks leaks and spills. Storage works best in a cool, dry spot, far from flames or heat. Experience has taught me never to stack new shipments near acids – a small mistake leads to big problems. Proper labeling discourages shortcuts; clear tags stop confusion, especially when you need to move things in a hurry.

Things Go Wrong—Be Ready

Spills don’t wait around for the right moment. Teams need quick access to spill kits with absorbent pads and neutralizers that really work for organotin compounds. We ran drills, even if folks grumbled, so nobody hesitated when something hit the floor. Emergency eye wash stations, showers, and first aid kits should be close by—preferably not buried under a lot of boxes. If someone breathes in the stuff or it hits bare skin, every second saved by good prep counts for a lot.

Training Never Ends

Teaching new people about tetrabutyltin isn’t just a box to tick. Continuous refreshers worked better than any wall sign. Sharing stories—bad spills, careless mistakes, and lucky escapes—kept safety real. Government agencies like OSHA and NIOSH offer guidelines and regulatory facts. Trusted sources say that repeated overexposure increases cancer risk and damages the nervous system. Sticking to protocols helps people get home safe, every shift.

Looking Ahead: Safer Choices and Smarter Practices

Some teams now substitute less hazardous materials, cutting the need for all this gear just to start the job. Better engineering controls, sensors, and stricter labeling cut the risk for everyone who steps onto the floor. Until chemistry gives us foolproof replacements, the habits we build around tetrabutyltin keep the work moving and the people healthy. Safety here isn’t about checking off a form—it's part of the job’s rhythm.

Tetrabutyltin
Tetrabutyltin
Tetrabutyltin
Names
Preferred IUPAC name tetrakis(butyl)stannane
Other names Tetrabutylstannane
Tetra-n-butyltin
Stannane, tetrabutyl-
Pronunciation /ˌtɛtrəˈbjuːtɪltɪn/
Identifiers
CAS Number 1461-25-2
Beilstein Reference 1719578
ChEBI CHEBI:30457
ChEMBL CHEMBL1629676
ChemSpider 21520
DrugBank DB14262
ECHA InfoCard EC100.095.098
EC Number 208-943-9
Gmelin Reference 79092
KEGG C19699
MeSH D014217
PubChem CID 11587
RTECS number WN0890000
UNII 85HH2L359E
UN number UN2536
CompTox Dashboard (EPA) DTXSID3022140
Properties
Chemical formula C16H36Sn
Molar mass 405.17 g/mol
Appearance Colorless transparent liquid
Odor pungent
Density 1.06 g/mL at 25 °C(lit.)
Solubility in water insoluble
log P 2.5
Vapor pressure 0.15 mmHg (20 °C)
Acidity (pKa) 13.5
Magnetic susceptibility (χ) -2260.0e-6 cm³/mol
Refractive index (nD) 1.490
Viscosity 6.3 mPa·s (25 °C)
Dipole moment 0 D
Thermochemistry
Std molar entropy (S⦵298) 527.6 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -198.7 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -6867 kJ·mol⁻¹
Pharmacology
ATC code V09CX01
Hazards
GHS labelling GHS02, GHS06, GHS08
Pictograms GHS02,GHS06,GHS08
Signal word Danger
Hazard statements H228, H301, H311, H331, H373, H410
Precautionary statements P280, P210, P260, P301+P310, P305+P351+P338, P331, P370+P378, P403+P233, P405, P501
NFPA 704 (fire diamond) 2-3-2
Flash point 72 °C
Autoignition temperature 250 °C
Explosive limits Explosive limits: 0.6–6.5% (in air)
Lethal dose or concentration LD50 oral rat 94 mg/kg
LD50 (median dose) LD50 (median dose): 25.6 mg/kg (intraperitoneal, rat)
NIOSH WH8575000
PEL (Permissible) PEL (Permissible Exposure Limit) for Tetrabutyltin: "0.1 mg/m³ (as Sn)
REL (Recommended) 0.2 mg/m³
IDLH (Immediate danger) 200 mg/m3
Related compounds
Related compounds Tetraethyltin
Tetramethyltin
Tetraoctyltin
Trimethyltin chloride